Fatal Case of Toxic Hepatitis Implicating Chlorpromazine

Fatal case of cephalexin-induced toxic epidermal necrolysis

PURPOSE To describe a case of toxic epidermal necrolysis likely caused by cephalexin with a review of the literature. CASE An 80-year-old male with a known allergy to cephalosporins, residing at a long-term acute care hospital, received cephalexin for a urinary tract infection. And 1 day after starting therapy, the patient developed an extensive erythematous rash accompanied by skin sloughing...

Alverine induced toxic hepatitis: a case report.

Drug-induced hepatotoxicity is an important cause of hepatocellular injury. Hepatic necrosis may range from asymptomatic elevations in transaminases to fulminant hepatic failure and death. Alverine is an antispasmodic drug which is especially used in patients with irritable bowel syndrome. Only a few cases of alverine associated hepatotoxicity have been reported previously. We present the case ...

A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine.

A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.

A Pediatric Case of Toxic Hepatitis Induced by Hovenia Dulcis

Toxic hepatitis is a rare but devastating disease in children. Herbs are widely used in oriental medicine to treat various symptoms in Korea, however, several herbs have been reported to induce liver injury. We report a case of toxic hepatitis induced by Hovenia dulcis in a 3-year-old boy. He complained of nausea, abdominal discomfort, and jaundice. The patient had consumed water boiled with ho...

Toxic epidermal necrolysis following chlorpromazine ingestion complicated by SIADH.